Anantapur district, officially Anantapuramu district, is one of the eight districts in the Rayalaseema region of the Indian state of Andhra Pradesh. The district headquarters is located in Anantapur city. It is one of the driest places in South India. In the year 2022, as part of re-organisation of districts, Sri Sathya Sai district was carved out.

Rayalaseema is a geographic region in the Indian state of Andhra Pradesh. It comprises four southern districts of the State, from prior to the districts reorganisation in 2022, namely Kurnool, Anantapur, YSR, and Chittoor. Four new districts were created from these, namely Sri Sathya Sai, Nandyal, Annamayya, and Tirupati. As of 2011 census of India, the western four districts of the region had a population of 15,184,908 and cover an area of 77,424 km2 (29,894 sq mi).