The Anatolic Theme, more properly known as the Theme of the Anatolics, was a Byzantine theme in central Asia Minor. From its establishment, it was the largest and senior-most of the themes, and its military governors (stratēgoi) were powerful individuals, several of them rising to the imperial throne or launching failed rebellions to capture it. The theme and its army played an important role in the Arab–Byzantine wars of the 7th–10th centuries, after which it enjoyed a period of relative peace that lasted until its conquest by the Seljuk Turks in the late 1070s.

The themes or thémata were the main military and administrative divisions of the middle Byzantine Empire. They were established in the mid-7th century in the aftermath of the Slavic migrations to Southeastern Europe and Muslim conquests of parts of Byzantine territory, and replaced the earlier provincial system established by Diocletian and Constantine the Great. In their origin, the first themes were created from the areas of encampment of the field armies of the East Roman army, and their names corresponded to the military units that had existed in those areas. The theme system reached its apogee in the 9th and 10th centuries, as older themes were split up and the conquest of territory resulted in the creation of new ones. The original theme system underwent significant changes in the 11th and 12th centuries, but the term remained in use as a provincial and financial circumscription until the very end of the Empire.