Andranik Nahapeti Margaryan served as the Prime Minister of Armenia from 12 May 2000, when the President appointed him, until his death on 25 March 2007. He was a member of the Republican Party of Armenia. He succeeded the Sargsyan brothers: Vazgen Sargsyan, who was murdered during the Armenian parliament shooting on 27 October 1999 and Aram Sargsyan, whom the President appointed a week later, but fired on 2 May 2000.

The prime minister of Armenia is the head of government and most senior minister within the Armenian government, and is required by the constitution to "determine the main directions of policy of the Government, manage the activities of the Government and coordinate the work of the members of the Government." Also, according to the constitution, the prime minister heads the Security Council, which prescribes the main directions of the country's defense policy; thus, the prime minister is effectively the commander-in-chief of the Armed Forces of Armenia. Nikol Pashinyan is the current prime minister. He took the office on 8 May 2018 following the resignation of Serzh Sargsyan.