Andrea Dovizioso is an Italian former professional motorcycle racer. He raced with WithU Yamaha RNF MotoGP Team for the 2022 season but announced his intended-retirement after the Misano round in September. Dovizioso was the 2004 125cc World Champion, but is best known for his time with the Ducati Team in the MotoGP class, finishing championship runner-up to Marc Márquez for three consecutive seasons in 2017, 2018 and 2019.

The 2022 FIM MotoGP World Championship was the premier class of the 74th F.I.M. Road Racing World Championship season. Fabio Quartararo came into the season as the defending World Champion. Ducati secured the constructors' championship, with the factory Ducati Lenovo Team securing the teams' championship and factory rider Francesco Bagnaia achieving the riders' championship. In total, seven different riders and five manufacturers won Grands Prix during the season. As the only manufacturer without a victory, the season saw Honda finish in last place of the manufacturers' standings for the first time in the modern MotoGP era.