Andrew Denton's Musical Challenge is an album released by Austereo in 2000 featuring musical challenges posed by radio comedian Andrew Denton to musicians, generally selecting a song in a style in contrast to their own. Following the success of the radio series, the album was released and then a second album followed in 2003, and later a compilation of the greatest of the two was released.

Andrew Christopher Denton is an Australian television producer, comedian, Gold Logie–nominated television presenter and former radio host, and was the host of the ABC's weekly television interview program Enough Rope and the ABC game show Randling. He is known for his comedy and interviewing technique. He is also responsible for introducing the troupe of The Chaser to Australian audiences.