Angel Mounds State Historic Site, an expression of the Mississippian culture, is an archaeological site managed by the Indiana State Museum and Historic Sites that includes more than 600 acres of land about 8 miles (13 km) southeast of present-day Evansville, in Vanderburgh and Warrick counties in Indiana. The large residential and agricultural community was constructed and inhabited from AD 1100 to AD 1450, and served as the political, cultural, and economic center of the Angel chiefdom. It extended within 120 miles (190 km) of the Ohio River valley to the Green River in present-day Kentucky. The town had as many as 1,000 inhabitants inside the walls at its peak, and included a complex of thirteen earthen mounds, hundreds of home sites, a palisade (stockade), and other structures.

The Mississippian culture was a Native American civilization that flourished in what is now the Midwestern, Eastern, and Southeastern United States from approximately 800 to 1600, varying regionally. It was known for building large, earthen platform mounds, and often other shaped mounds as well. It was composed of a series of urban settlements and satellite villages linked together by loose trading networks. The largest city was Cahokia, believed to be a major religious center located in what is present-day southern Illinois.