Angleton High School is a public high school located just outside the city of Angleton, Texas, United States in unincorporated Brazoria County. It is classified as a 5A school by the University Interscholastic League (UIL). It is a part of the Angleton Independent School District located in south central Brazoria County. For the 2021-2022 school year, the school was given a "B" by the Texas Education Agency.

Angleton is a city in and the county seat of Brazoria County, Texas, United States, within the Houston–The Woodlands–Sugar Land metropolitan area. Angleton lies at the intersection of State Highway 288, State Highway 35, and the Union Pacific Railroad. The population was 19,429 at the 2020 census. Angleton is in the 14th congressional district, and is represented by Republican Congressman Randy Weber.