Angleton ISD is a public school district in Angleton, Texas (USA), operating 5 levels of education. Established in 1897, AISD encompasses 396 square miles (1,030 km2) in Brazoria County, serving Angleton as well as the Village of Bonney, the Sandy Point census-designated place, parts of the CDP of Rosharon, and the unincorporated areas of Chocolate Bayou, Lochridge, and Otey.

Angleton is a city in and the county seat of Brazoria County, Texas, United States, within the Houston–The Woodlands–Sugar Land metropolitan area. Angleton lies at the intersection of State Highway 288, State Highway 35, and the Union Pacific Railroad. The population was 19,429 at the 2020 census. Angleton is in the 14th congressional district, and is represented by Republican Congressman Randy Weber.