Anhalt-Bernburg was a principality of the Holy Roman Empire and a duchy of the German Confederation ruled by the House of Ascania with its residence at Bernburg in present-day Saxony-Anhalt. It emerged as a subdivision from the Principality of Anhalt from 1252 until 1468, when it fell to the Ascanian principality of Anhalt-Dessau. Recreated in 1603, Anhalt-Bernburg finally merged into the re-unified Duchy of Anhalt upon the extinction of the line in 1863.

Lebrecht, Prince of Anhalt-Zeitz-Hoym, was a German prince of the House of Ascania.