Animation Domination is an American animated programming block that has aired in two iterations on the Fox broadcast network, featuring a lineup solely made up of prime-time animation and adult animation carried as a majority of, or the whole of, the network's Sunday evening schedule. It originally ran from May 1, 2005, until September 21, 2014, before returning on September 29, 2019.

American Dad! is an American animated sitcom created by Seth MacFarlane, Mike Barker and Matt Weitzman for the Fox Broadcasting Company. The series was moved to TBS in 2014 and continues to air new episodes to this day. American Dad! is the first television series made to premiere on Fox's Animation Domination block. The series premiered on February 6, 2005, following Super Bowl XXXIX, with the rest of the first season airing three months later beginning May 1, 2005.