The Anniston–Oxford metropolitan statistical area is the second-most populated metropolitan area in Northeast Alabama, behind Huntsville. At the 2000 census, it had a population of 112,249. The MSA is anchored by significant jobs at Jacksonville State University, the Northeast Alabama Regional Medical Center, Stringfellow Hospital, the Anniston Army Depot, and the Department of Homeland Security at McClellan. McClellan has transitioned from being a closed military base, to becoming the home of hundreds of residents, new retail growth such as a Lowe's Home Improvement Store, and now more than 3,000 jobs spread out over more than 20 employers. Anniston remains strong in health care, legal, financial services and manufacturing. Oxford, with Interstate 20 running right through it, has developed a number of retail and restaurant establishments including the Oxford Exchange which is anchored by Target.

Anniston is the county seat of Calhoun County in Alabama, United States, and is one of two urban centers/principal cities of and included in the Anniston-Oxford Metropolitan Statistical Area. As of the 2010 census, the population of the city was 23,106. According to 2019 Census estimates, the city had a population of 21,287. Named "The Model City" by Atlanta newspaperman Henry W. Grady for its careful planning in the late 19th century, the city is situated on the slope of Blue Mountain.