Pontocerebellar hypoplasia is a heterogeneous group of rare neurodegenerative disorders caused by genetic mutations and characterised by progressive atrophy of various parts of the brain such as the cerebellum or brainstem. Where known, these disorders are inherited in an autosomal recessive fashion. There is no known cure for PCH. There are different signs and symptoms for different forms of pontocerebellar hypoplasia, at least six of which have been described by researchers. All forms involve abnormal development of the brain, leading to slow development, movement problems, intellectual impairment; the following values seem to be aberrant in children with CASK gene defects: lactate, pyruvate, 2-ketoglutaric acid, adipic acid, suberic acid which seems to support the thesis that CASK affects mitochondrial function. Pontocerebellar hypoplasia is caused by mutations in genes including VRK1; the genes associated with PCH3 and PCH5 have not yet been identified. The mutated genes in PCH are autosomal recessive, which means that parents of an affected child each carry only one copy of the damaged gene.
In each parent the other copy performs its proper function and they display no signs of PCH. A child inheriting two damaged copies of the gene will be affected by PCH. Mutations in the genes that cause PCH produce faults in the production of chemicals enzymes, that are required for the development of nerve cells and for properly processing RNA, needed for any cell to function normally; the exact mechanism by which PCH affects the development of the cerebellum and pons is not well understood. Pontocerebellar hypoplasia is classified as follows: Pontine and cerebellar hypoplasia is observed in certain phenotypes of X-linked mental retardation – so called MICPCH. Another gene, associated with this condition is coenzyme A synthase; the severity of different forms of PCH varies, but many children inheriting the mutated gene responsible do not survive infancy or childhood. Mental retardation and microcephaly with pontine and cerebellar hypoplasia
Yoshiro Moriyama is a former Japanese football player. He played for Japan national team. Moriyama was born in Kumamoto on November 9, 1967. After graduating from University of Tsukuba, he joined Mazda in 1991; the club won the 2nd place in 1995 Emperor's Cup. He moved to Yokohama Flügels in 1996, Júbilo Iwata in 1998 and Bellmare Hiratsuka in 1999, he retired end of 1999 season. On July 8, 1994, Moriyama debuted for Japan national team against Ghana, he was selected Japan for 1994 Asian Games and played all matches. He played 7 games for Japan in 1994. Yoshiro Moriyama at National-Football-Teams.com Japan National Football Team Database Yoshiro Moriyama at J. League