Antelope squirrels or antelope ground squirrels of the genus Ammospermophilus are sciurids found in the desert and dry scrub areas of the southwestern United States and northern Mexico. They are a type of ground squirrel and are able to resist hyperthermia and can survive body temperatures over 40 °C (104 °F).

Ground squirrels are rodents of the squirrel family (Sciuridae) that generally live on the ground or in burrows, rather than in trees like the tree squirrels. The term is most often used for the medium-sized ground squirrels, as the larger ones are more commonly known as marmots or prairie dogs, while the smaller and less bushy-tailed ground squirrels tend to be known as chipmunks.