Anti-Catholicism in the United States concerns the anti-Catholic attitudes which were first brought to the Thirteen Colonies by Protestant European settlers, mostly composed of English Puritans, during the British colonization of North America. Two types of anti-Catholic rhetoric existed in colonial society and they continued to exist during the following centuries. The first type, derived from the theological heritage of the Protestant Reformation and the European wars of religion, consisted of the biblical Anti-Christ and the Whore of Babylon variety and it dominated anti-Catholic thought until the late 17th century. The second type was a variety which was partially derived from xenophobic, ethnocentric, nativist, and racist sentiments and distrust of increasing waves of Catholic immigrants, particularly immigrants from Ireland, Italy, Poland, Germany, Austria and Mexico. It usually focused on the pope's control of bishops, priests, and deacons.

Nativism is the political policy of promoting or protecting the interests of "native-born" or established inhabitants over those of immigrants, including the support of anti-immigration and immigration-restriction measures. Despite the name, and in the US in particular, this position is usually held by the descendants of immigrants themselves, and is not a movement led by Indigenous peoples, as opposited to Nativists in Europe who are descended from native peoples such as Celts, Anglo-Saxons or Norsemen.