The Antimafia Commission is a bicameral commission of the Italian Parliament, composed of members from the Chamber of Deputies and the Senate of the Republic. The first commission, formed in 1963, was established as a body of inquiry tasked with investigating the "phenomenon of the [Sicilian] Mafia". Subsequent commissions expanded their scope to investigate all "organized crime of the Mafia type", which included other major criminal organizations in Italy, such as the Camorra, the 'Ndrangheta, and the Sacra Corona Unita.

Criminal organizations have been prevalent in Italy, especially in the southern part of the country, for centuries and have affected the social and economic life of many Italian regions. There are major native mafia-like organizations that are heavily active in Italy. The most powerful of these organizations are the 'Ndrangheta from Calabria, the Cosa Nostra from Sicily, and the Camorra from Campania.