Antioch on the Orontes was a Hellenistic Greek city founded by Seleucus I Nicator in 300 BC. It was one of the greatest and most important Greek cities of the Hellenistic period. The city served as the capital of the Greek Seleucid Empire and later as regional capital to both the Roman and Byzantine Empire. During the Crusades, Antioch served as the capital of the Principality of Antioch, one of four Crusader states that were founded in the Levant. The modern city of Antakya, in Hatay Province of Turkey, was named after the ancient city, which lies in ruins on the Orontes River and did not overlap in habitation with the modern city.

Hellenistic Greece is the historical period of the country following Classical Greece, between the death of Alexander the Great in 323 BC and the annexation of the classical Greek Achaean League heartlands by the Roman Republic. This culminated at the Battle of Corinth in 146 BC, a crushing Roman victory in the Peloponnese that led to the destruction of Corinth and ushered in the period of Roman Greece. Hellenistic Greece's definitive end was with the Battle of Actium in 31 BC, when the future emperor Augustus defeated Greek Ptolemaic queen Cleopatra VII and Mark Antony, the next year taking over Alexandria, the last great center of Hellenistic Greece.