Antioch High School is a public high school located in Antioch, California, United States. It is located at 700 West 18th Street between G and L streets. It is a comprehensive high school for grades 9-12. There are about 120 teachers, and 20 maintenance and office staff. The administration consists of a principal and four vice principals. Departments at the school include English; mathematics; physical, earth, and life sciences; social studies; physical education; vocal and instrumental music; video, photographic, sculpted, painted and drawn arts; foreign languages; health and sports medicine; auto and wood shop; and engineering.

Antioch is the third-largest city in Contra Costa County, California, United States. The city is located in the East Bay region of the San Francisco Bay Area along the Sacramento–San Joaquin River Delta. The city's population was 115,291 at the 2020 census. The city has grown substantially more diverse since the 1970s.