Antioch Missionary Baptist Church is a historic Baptist church at 500 Clay St in Downtown Houston, Texas. It was historically a part of the Fourth Ward. As of 2012 it was the only remaining piece of the original Fourth Ward east of Interstate 45.

Fourth Ward is one of the historic six wards of Houston, Texas, United States. The Fourth Ward is located inside the 610 Loop directly west of and adjacent to Downtown Houston. The Fourth Ward is the site of Freedmen's Town, which was a post-U.S. Civil War community of African-Americans.