Anwar Nasser Abdulla al-Awlaki was an American-Yemeni Islamic scholar, lecturer, and jihadist who was killed in 2011 in Yemen by a U.S. government drone strike ordered by President Barack Obama. Al-Awlaki became the first U.S. citizen to be targeted and killed by a drone strike from the U.S. government. U.S. government officials have stated that al-Awlaki was a key organizer for the Islamist terrorist group al-Qaeda.

The Disposition Matrix, informally known as a kill list, is a database of information for tracking, capturing, rendering, or killing suspected enemies of the United States. Developed by the Obama administration beginning in 2010, it goes beyond existing kill lists and is intended to become a permanent fixture of U.S. policy. The process determining the criteria for killing is not public and was heavily shaped by National Counterterrorism Director and former Central Intelligence Agency (CIA) Director John O. Brennan.