The Apostolic Nunciature to Mexico the diplomatic mission of the Holy See to Mexico. It is located in Álvaro Obregón, Mexico City. The current Apostolic Nuncio is Bishop Joseph Spiteri, who was named to the position by Pope Francis on 7 July 2022.

An apostolic nunciature is a top-level diplomatic mission of the Holy See that is equivalent to an embassy. However, it neither issues visas nor has consulates.