Appleton is a city in and the county seat of Outagamie County, Wisconsin, United States. A small portion of the city also extends into Calumet and Winnebago counties. It is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. As of the 2020 census, it had a population of 75,644, making it the sixth-most populous city in Wisconsin. Appleton is part of the Fox Cities metropolitan area, the third-largest metro area in the state with over 415,000 residents.

The Fox River is a river in eastern Wisconsin in the Great Lakes region of the United States. It is the principal tributary of Green Bay, and via the Bay, the largest tributary of Lake Michigan. The city of Green Bay, one of the first European settlements in the interior of North America, is on the river at its mouth on lower Green Bay.