Appleton is a city in and the county seat of Outagamie County, Wisconsin, United States. A small portion of the city also extends into Calumet and Winnebago counties. It is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. As of the 2020 census, it had a population of 75,644, making it the sixth-most populous city in Wisconsin. Appleton is part of the Fox Cities metropolitan area, the third-largest metro area in the state with over 415,000 residents.

Outagamie County is a county in the Fox Cities region of the U.S. state of Wisconsin, located in the northeast of the state. As of the 2020 Census, the population was 190,705. Its county seat is Appleton.