The Appleton Museum of Art is an art museum located in Ocala, Florida. It is affiliated with and governed by the College of Central Florida and has been since 2004.

Ocala is a city in and the county seat of Marion County, Florida, United States. Located in North Central Florida, the city's population was 63,591 as of the 2020 census, up from 56,315 at the 2010 census, making it the 43rd-most populated city in Florida. Ocala is the principal city of the Ocala, Florida Metropolitan Statistical Area, which had a population of 375,908 in 2020.