Appomattox County is a United States county located in the Piedmont region and near the center of the Commonwealth of Virginia. The county is part of the Lynchburg, VA Metropolitan Statistical Area, and its county seat is the town of Appomattox.

The Lynchburg Metropolitan Statistical Area is a United States Metropolitan Statistical Area (MSA) in the state of Virginia, as defined by the Office of Management and Budget (OMB) as of June 2003. As of the 2000 census, the MSA had a population of 228,616. In 2009 this was estimated to have risen to 247,447; as of 2016, the Lynchburg MSA was estimated to have a population of 260,320, making it the fifth-largest metro area in the state.