The Appomattox River is a tributary of the James River, approximately 157 miles (253 km) long, in central and eastern Virginia, named for the Appomattocs Indian tribe who lived along its lower banks in the 17th century. It drains a cotton and tobacco-growing region of the Piedmont and coastal plain southwest of Richmond.

The James River is a river in Virginia that begins in the Appalachian Mountains and flows from the confluence of the Cowpasture and Jackson Rivers in Botetourt County 348 miles (560 km) to the Chesapeake Bay. The river length extends to 444 miles (715 km) if the Jackson River is included, the longer of its two headwaters. It is the longest river in Virginia. Jamestown and Williamsburg, Virginia's first colonial capitals, and Richmond, Virginia's current capital, lie on the James River.