The Appomattox River is a tributary of the James River, approximately 157 miles (253 km) long, in central and eastern Virginia, named for the Appomattocs Indian tribe who lived along its lower banks in the 17th century. It drains a cotton and tobacco-growing region of the Piedmont and coastal plain southwest of Richmond.

Appomattox County is a United States county located in the Piedmont region and near the center of the Commonwealth of Virginia. The county is part of the Lynchburg, VA Metropolitan Statistical Area, and its county seat is the town of Appomattox.