The Archdiocesan Cathedral of the Holy Trinity, at 319–337 East 74th Street on the Upper East Side of Manhattan in New York City, is a Neo-Byzantine-style Greek Orthodox church. It serves as the national cathedral of the Greek Orthodox Archdiocese of America, and as the episcopal seat of Archbishop Elpidophoros of America.

74th Street is an east–west street carrying pedestrian traffic and eastbound automotive/bicycle traffic in the New York City borough of Manhattan. It runs through the Upper East Side neighborhood, and the Upper West Side neighborhood, on both sides of Central Park.