The Arctic National Wildlife Refuge or Arctic Refuge is a national wildlife refuge in northeastern Alaska, United States, on traditional Iñupiaq and Gwich'in lands. The refuge is 19,286,722 acres (78,050.59 km2) of the Alaska North Slope region, with a northern coastline and vast inland forest, taiga, and tundra regions. ANWR is the largest national wildlife refuge in the country, slightly larger than the Yukon Delta National Wildlife Refuge. The refuge is administered from offices in Fairbanks. ANWR is home to a diverse range of endemic mammal species; notably, it is one of the few North American locations with all three endemic American ursids—the polar bear, grizzly bear, and American black bear, each of which resides predominantly in its own ecological niche. Besides the bears, other mammal species include the moose, caribou, wolves, red and Arctic fox, Canada lynx, wolverine, pine marten, American beaver, and North American river otter. Further inland, mountain goats may be seen near the slope. Hundreds of species of migratory birds visit the refuge yearly, and it is a vital, protected breeding location for them. Snow geese, eiders and snowy owls may be observed as well.

Alaska is a non-contiguous U.S. state on the northwest extremity of North America. It borders the Canadian province of British Columbia and the Yukon territory to the east; it shares a western maritime border in the Bering Strait with Russia's Chukotka Autonomous Okrug. The Chukchi and Beaufort Seas of the Arctic Ocean lie to the north and the Pacific Ocean lies to the south. Technically a semi-exclave of the U.S., it is the largest exclave in the world.