Aripuanã River is a river in the Mato Grosso and Amazonas states in north-western Brazil. It is a tributary of the Madeira River in the Amazon Basin. The town of Novo Aripuanã is located on its banks where it merges into the Madeira River. The town of Aripuanã is also on its banks, but on the upper (southern) section of the river.

The Madeira River is a major waterway in South America. It is estimated to be 1,450 km (900 mi) in length, while the Madeira-Mamoré is estimated near 3,250 km (2,020 mi) or 3,380 km (2,100 mi) in length depending on the measuring party and their methods. The Madeira is the biggest tributary of the Amazon, accounting for about 15% of the water in the basin. A map from Emanuel Bowen in 1747, held by the David Rumsey Map Collection, refers to the Madeira by the pre-colonial, indigenous name Cuyari. The River of Cuyari, called by the Portuguese Madeira or the Wood River, is formed by two great rivers, which join near its mouth. It was by this River, that the Nation of Topinambes passed into the River Amazon.