The Arkansas–Ole Miss football rivalry is an American college football rivalry between the Arkansas Razorbacks football team of the University of Arkansas and the Ole Miss Rebels football team of the University of Mississippi. The teams first met in 1908, and have played each other every year since 1981. Arkansas leads the series, which includes two wins by Ole Miss in postseason bowl games, the 1963 and 1970 Sugar Bowls.

The Arkansas Razorbacks football program represents the University of Arkansas in the sport of American football. The Razorbacks compete in the Football Bowl Subdivision (FBS) of the National Collegiate Athletic Association (NCAA) and the Western Division of the Southeastern Conference (SEC). The program has one national championship awarded by the Football Writers Association of America (FWAA) and Helms Athletic Foundation (HAF) in 1964 and one national championship awarded by the Rothman Foundation for the Analysis of Competitions and Tournaments in 1977. The school does not claim the 1977 title. The program began in 1894 and has compiled an all-time record of 740–539–40, for a .576 winning percentage. The Razorbacks have won 13 conference championships and have had 58 players named honored as All-Americans.