Highway 1 is a north–south state highway in east Arkansas. The route of 159.88 miles (257.30 km) runs from US Route 278 (US 278) in McGehee north to Supplemental Route BB at the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately 50 miles (80 km) with U.S. Route 49.

U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.