Highway 259 is a designation for three north–south state highways in northeast Arkansas. A southern route of 12.11 miles (19.49 km) runs north from Highway 238 to US Route 70 (US 70) at Lake Grove, Arkansas. A second route of 6.90 miles (11.10 km) begins at Highway 306 and runs north to Highway 284 in Cross County. A third route of 3.14 miles (5.05 km) begins at Highway 364 and runs north to Highway 42 near Hickory Ridge.

Highway 238 is an east–west state highway in the Lower Arkansas Delta. The route of 17.57 miles (28.28 km) begins at US Highway 49/US Highway 70 in Brinkley and runs east to US 79 near Moro. The route is maintained by the Arkansas State Highway and Transportation Department (AHTD).