Highway 324 is a designation for four state highways in the Arkansas River Valley. One route of 0.76 miles (1.22 km) runs from US Highway 64 (US 64) to Tyler Road in Russellville. A second route of 6.85 miles (11.02 km) begins at Highway 105 and runs east around Lake Atkins to terminate at Highway 105. A third route of 4.01 miles (6.45 km) connects Highway 155 and Highway 10 in Perry County. A fourth segment connects Lake Sylvia Recreational Area in the Ouachita National Forest to Highway 9 and the state highway system. All routes are maintained by the Arkansas State Highway and Transportation Department (AHTD).

U.S. Route 64 is a U.S. highway running from Teec Nos Pos, Arizona east to Nags Head, North Carolina. In the U.S. state of Arkansas, the route runs 246.35 miles (396.46 km) from the Oklahoma border in Fort Smith east to the Tennessee border in Memphis. The route passes through several cities and towns, including Fort Smith, Clarksville, Russellville, Conway, Searcy, and West Memphis. US 64 runs parallel to Interstate 40 until Conway, when I-40 takes a more southerly route.