Arrestin
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Arrestins are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step
Structure of arrestin from bovine rod outer segments.
Structure of bovine beta-arrestin.
Crystal structure showing where arrestin will precisely bound to activated and phosphorylated rhodopsin at key residues
Clathrin
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Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains
Arrestin
…heterotrimeric G-protein, preventing its activation (desensitization). Second, arrestin links the receptor to elements of the internalization machinery, clathrin and clathrin adaptor AP2, which promotes receptor internalization via coated pits and subsequent transport to internal compartments, called endosomes…
Clathrin terminal domain
clathrin heavy chain proximal repeat (linker)
Mechanism of clathrin-mediated endocytosis.