The Arsacid dynasty, called the Arshakuni in Armenian, ruled the Kingdom of Armenia, with some interruptions, from 12 to 428. The dynasty was a branch of the Arsacid dynasty of Parthia. Arsacid kings reigned intermittently throughout the chaotic years following the fall of the Artaxiad dynasty until 62, when Tiridates I, brother of Parthian King Vologases I, secured Arsacid rule in Armenia as a client king of Rome. However, he did not succeed in establishing his line on the throne, and various princes of different Arsacid lineages ruled until the accession of Vologases II, who succeeded in establishing his own line on the Armenian throne, which ruled the kingdom until its abolishment by the Sasanian Empire in 428.

Armenia, also the Kingdom of Greater Armenia, or simply Greater Armenia or Armenia Major sometimes referred to as the Armenian Empire, was a kingdom in the Ancient Near East which existed from 331 BC to 428 AD. Its history is divided into the successive reigns of three royal dynasties: Orontid, Artaxiad and Arsacid (52–428).