The Arsacid dynasty, called the Arshakuni in Armenian, ruled the Kingdom of Armenia, with some interruptions, from 12 to 428. The dynasty was a branch of the Arsacid dynasty of Parthia. Arsacid kings reigned intermittently throughout the chaotic years following the fall of the Artaxiad dynasty until 62, when Tiridates I, brother of Parthian King Vologases I, secured Arsacid rule in Armenia as a client king of Rome. However, he did not succeed in establishing his line on the throne, and various princes of different Arsacid lineages ruled until the accession of Vologases II, who succeeded in establishing his own line on the Armenian throne, which ruled the kingdom until its abolishment by the Sasanian Empire in 428.

The Parthian Empire, also known as the Arsacid Empire, was a major Iranian political and cultural power centered in ancient Iran from 247 BC to 224 AD. Its latter name comes from its founder, Arsaces I, who led the Parni tribe in conquering the region of Parthia in Iran's northeast, then a satrapy (province) under Andragoras, who was rebelling against the Seleucid Empire. Mithridates I greatly expanded the empire by seizing Media and Mesopotamia from the Seleucids. At its height, the Parthian Empire stretched from the northern reaches of the Euphrates, in what is now central-eastern Turkey, to present-day Afghanistan and western Pakistan. The empire, located on the Silk Road trade route between the Roman Empire in the Mediterranean Basin and the Han dynasty of China, became a center of trade and commerce.