ArtScience Museum is a museum within the integrated resort of Marina Bay Sands in the Downtown Core of the Central Area in Singapore. Opened on 17 February 2011 by Singapore's prime minister, Lee Hsien Loong, it features major exhibitions that blend art, science, culture and technology.

Marina Bay Sands is an integrated resort fronting Marina Bay in Singapore and a landmark of the city. At its opening in 2010, it was deemed the world's most expensive standalone casino property at S$8 billion (US$6.88 billion). The resort includes a 2,561-room hotel, a 120,000-square-metre (1,300,000 sq ft) convention-exhibition centre, the 74,000-square-metre (800,000 sq ft) The Shoppes at Marina Bay Sands mall, a museum, a large theatre, "celebrity chef" restaurants, two floating crystal pavilions, art-science exhibits, and the world's largest atrium casino with 500 tables and 1,600 slot machines. The complex includes three towers topped by the Sands Skypark, a skyway connecting 340-metre-long (1,120 ft) with a capacity of 3,902 people and a 150 m (490 ft) infinity swimming pool, set on top of the world's largest public cantilevered platform, which overhangs the north tower by 66.5 m (218 ft). The 20-hectare resort was designed by Moshe Safdie architects.