Artemis 3 is planned to be the first crewed Moon landing mission of the Artemis program and the first crewed flight of the Starship HLS lander. Artemis 3 is planned to be the second crewed Artemis mission and the first American crewed lunar landing since Apollo 17 in December 1972. In December 2023, the Government Accountability Office reported that the mission is not likely to occur before 2027; as of January 2024, NASA officially expects Artemis 3 to launch no earlier than September 2026 due to issues with the valves in Orion's life support system.

The Artemis program is a Moon exploration program that is led by the United States' NASA and was formally established in 2017 via Space Policy Directive 1. The Artemis program is intended to reestablish a human presence on the Moon for the first time since Apollo 17 in 1972. The program's stated long-term goal is to establish a permanent base on the Moon to facilitate human missions to Mars.