Artemis 4 is a planned mission of the NASA-led Artemis program. The mission will include the fourth use of a Space Launch System (SLS) launch vehicle, will send an Orion spacecraft with four astronauts to the Lunar Gateway space station, install a new module on the Gateway, and conduct the second lunar landing of the Artemis program.

The Artemis program is a Moon exploration program that is led by the United States' National Aeronoautics and Space Administration (NASA) and was formally established in 2017 via Space Policy Directive 1. The Artemis program is intended to reestablish a human presence on the Moon for the first time since the Apollo 17 moon mission in 1972. The program's stated long-term goal is to establish a permanent base on the Moon to facilitate human missions to Mars.