Artemis 5 is the fifth planned mission of NASA's Artemis program and the first crewed flight of the Blue Moon lander. The mission will launch four astronauts on a Space Launch System rocket and an Orion to the Lunar Gateway and will be the third lunar landing of the Artemis program. In addition, Artemis V will also deliver two new elements to the Gateway Space Station.

The Artemis program is a Moon exploration program that is led by the United States' National Aeronoautics and Space Administration (NASA) and was formally established in 2017 via Space Policy Directive 1. The Artemis program is intended to reestablish a human presence on the Moon for the first time since the Apollo 17 moon mission in 1972. The program's stated long-term goal is to establish a permanent base on the Moon to facilitate human missions to Mars.