The Ash Meadows National Wildlife Refuge is a protected wildlife refuge located in the Amargosa Valley of southern Nye County, in southwestern Nevada. It is directly east of Death Valley National Park, and is 90 mi (140 km) west-northwest of Las Vegas.

The Amargosa Valley is the valley through which the Amargosa River flows south, in Nye County, southwestern Nevada and Inyo County in the state of California. The south end is alternately called the "Amargosa River Valley'" or the "Tecopa Valley." Its northernmost point is around Beatty, Nevada and southernmost is Tecopa, California, where the Amargosa River enters into the Amargosa Canyon.