Ashland County is a county located in the northeastern portion of the U.S. state of Ohio. As of the 2020 census, the population was 52,447. Its county seat and largest city is Ashland. The county is named for "Ashland", the home of Senator Henry Clay near Lexington, Kentucky. It was formed in 1846 from parts of Huron, Lorain, Richland and Wayne Counties.

Holmes County is a county in the U.S. state of Ohio. As of the 2020 Census, the population was 44,223. Its county seat is Millersburg. The county was formed in 1824 from portions of Coshocton, Tuscarawas and Wayne counties and organized the following year. It was named after Andrew Holmes, an officer killed in the War of 1812.