Ashley County is a rural South Arkansas county with a culture, economy, and history based on timber and agriculture. Created as Arkansas's 52nd county on November 30, 1848, Ashley County has seven incorporated municipalities, including Hamburg, the county seat and Crossett, the most populous city. The county is also the site of numerous unincorporated communities and ghost towns. The county is named for Chester Ashley, a prominent lawyer in the Arkansas Territory and U.S. senator from the state from 1844 to 1848.

U.S. Route 165 is a north–south United States highway spur of U.S. Highway 65. It currently runs for 412 miles (663 km) from U.S. Route 90 in Iowa, Louisiana north to U.S. Highway 70 in North Little Rock, Arkansas. The route passes through the states of Arkansas and Louisiana. It passes through the cities of Monroe and Alexandria in Louisiana. A segment of US 165 serves as a routing of the Great River Road within Arkansas.