Jovenel Moïse, the 43rd president of Haiti, was assassinated on 7 July 2021 at 1 am EDT (UTC−04:00) at his residence in Port-au-Prince. A group of 28 foreign mercenaries, mostly from Colombia, are alleged to be responsible for the killing. First Lady Martine Moïse was also shot multiple times in the attack, and was airlifted to the United States for emergency treatment. Later in the day, USGPN killed three of the suspected assassins and arrested 20 more. A manhunt was launched for other gunmen as well as the masterminds of the attack. Haitian chief prosecutor Bedford Claude confirmed plans to question Moïse's top bodyguards; none of the president's security guards were killed or injured in the attack. US authorities have since arrested eleven suspects alleged to have conspired in the assassination. Martine Moïse and former prime minister Claude Joseph were formally charged on 19 February 2024 with conspiring in the assassination.

Jovenel Moïse was a Haitian politician and entrepreneur, who served as the 43rd president of Haiti from 2017 until his assassination in 2021. He assumed the presidency in February 2017 after winning the November 2016 election. During his term, Haiti experienced widespread protests and unrest. In the early morning of 7 July 2021, Moïse was assassinated, and his wife Martine was injured during an attack on their private residence in Pétion-Ville. Claude Joseph assumed the role of acting president in the aftermath of Moïse's assassination.