Assisi Cathedral, dedicated to San Rufino, is a major church in Assisi, Italy. This stately church in Umbrian Romanesque style was the third church built on the same site to contain the remains of bishop Rufinus of Assisi, martyred in the 3rd century. The construction was started in 1140 to the designs by Giovanni da Gubbio, as attested by the wall inscription visible inside the apse. He may be the same Giovanni who designed the rose-window on the façade of Santa Maria Maggiore in 1163.

Assisi is a town and comune of Italy in the Province of Perugia in the Umbria region, on the western flank of Monte Subasio.