Assyrian Americans refers to individuals of ethnic Assyrian ancestry born in or residing within the United States. Assyrians are an indigenous Middle Eastern ethnic group native to Mesopotamia in West Asia who descend from their ancient counterparts, directly originating from the ancient indigenous Mesopotamians of Akkad and Sumer who first developed the independent civilisation in northern Mesopotamia that would become Assyria in 2600 BC. Modern Assyrians often culturally self-identify as Syriacs, Chaldeans, or Arameans for religious and tribal identification. The first significant wave of Assyrian immigration to the United States was due to the Sayfo genocide in the Assyrian homeland in 1914–1924.

Assyrian continuity is the study of continuity between the modern Assyrian people, a Semitic indigenous ethnic, religious, and linguistic minority in the Middle East, and the people of Ancient Mesopotamia in general and ancient Assyria in particular. Assyrian continuity and Mesopotamian heritage is a key part of the identity of the modern Assyrian people. No archaeological, genetic, linguistic, anthropological, or written historical evidence exists of the original Assyrian and Mesopotamian population being exterminated, removed, bred out, or replaced in the aftermath of the fall of the Assyrian Empire, modern contemporary scholarship "almost unilaterally" supports Assyrian continuity, recognizing the modern Assyrians as the ethnic, linguistic, historical, and genetic descendants of the East Assyrian-speaking population of Bronze Age and Iron Age Assyria specifically, and Mesopotamia in general, which were composed of both the old native Assyrian population and of neighboring settlers in the Assyrian heartland.