The Athlon 64 X2 is the first native dual-core desktop central processing unit (CPU) designed by Advanced Micro Devices (AMD). It was designed from scratch as native dual-core by using an already multi-CPU enabled Athlon 64, joining it with another functional core on one die, and connecting both via a shared dual-channel memory controller/north bridge and additional control logic. The initial versions are based on the E stepping model of the Athlon 64 and, depending on the model, have either 512 or 1024 KB of L2 cache per core. The Athlon 64 X2 can decode instructions for Streaming SIMD Extensions 3 (SSE3), except those few specific to Intel's architecture. The first Athlon 64 X2 CPUs were released in May 2005, in the same month as Intel's first dual-core processor, the Pentium D.

Pentium D is a range of desktop 64-bit x86-64 processors based on the NetBurst microarchitecture, which is the dual-core variant of the Pentium 4 manufactured by Intel. Each CPU comprised two cores. The brand's first processor, codenamed Smithfield and manufactured on the 90 nm process, was released on May 25, 2005, followed by the 65 nm Presler nine months later. The core implementation on the 90 nm "Smithfield" and later 65 nm "Presler" are designed differently but are functionally the same. The 90 nm "Smithfield" contains a single die, with two adjoined but functionally separate CPU cores cut from the same wafer. The later 65 nm "Presler" utilized a multi-chip module package, where two discrete dies each containing a single core reside on the CPU substrate. Neither the 90nm "Smithfield" nor the 65 nm "Presler" were capable of direct core to core communication, relying instead on the northbridge link to send information between the 2 cores.