Atlético Nacional S. A., best known as Atlético Nacional, is a Colombian professional football club based in Medellín. The club is one of only three clubs to have played in every first division tournament in the country's history, the other two being Millonarios and Santa Fe.

Medellín, officially the Special District of Science, Technology and Innovation of Medellín, is the second-largest city in Colombia after Bogotá, and the capital of the department of Antioquia. It is located in the Aburrá Valley, a central region of the Andes Mountains, in northwestern South America. The city's population was 2,508,452 at the 2018 census. The metro area of Medellín is the second-largest urban agglomeration in Colombia in terms of population and economy, with more than 4 million people.