The Augusta AVA was established on June 20, 1980 as the first federally approved American Viticultural Area, eight months before the Napa Valley AVA in northern California. The petition was submitted by Clayton W. Byers and Lucian W. Dressel, representing the local wine industry, to the Director of the Bureau of Alcohol, Tobacco and Firearms on October 16, 1978. Located entirely within the state of Missouri, the boundaries of this wine region encompass 15 square miles (39 km2) around the city of Augusta near the intersection of St. Charles County, Warren County and Franklin County.

St. Charles County is in the central eastern part of the U.S. state of Missouri. As of the 2020 census, the population was 405,262, making it Missouri's third-most populous county. Its county seat is St. Charles. The county was organized October 1, 1812, and named for Saint Charles Borromeo, an Italian cardinal.