Auntie Mame: An Irreverent Escapade is a 1955 novel by American author Patrick Dennis chronicling the madcap adventures of a boy, Patrick, growing up as the ward of his Aunt Mame Dennis, the sister of his dead father.

Edward Everett Tanner III, known by the pseudonym Patrick Dennis, was an American author. His novel Auntie Mame: An irreverent escapade (1955) was one of the bestselling American books of the 20th century. In chronological vignettes, the narrator — also named Patrick — recalls his adventures growing up under the wing of his madcap aunt, Mame Dennis. Tanner wrote a sequel, titled Around the World with Auntie Mame, in 1958. He based the character of Mame Dennis on his father's sister, Marion Tanner. Tanner also wrote several novels under the pseudonym Virginia Rowans.