Australia competed at the 2012 Summer Paralympics Games in London, United Kingdom, from 29 August to 9 September 2012. The London Games were the biggest Games with 164 nations participating, 19 more than in the 2008 Beijing Paralympic. Australia has participated at every Summer Paralympic Games and hosted the 2000 Sydney Games. As such, the 2000 Sydney Games, regarded as one of the more successful Games, became a point-of-reference and an inspiration in the development of the 2012 London Games.

Paralympics Australia (PA) previously called the Australian Paralympic Committee (APC) (1998–2019) is the National Paralympic Committee in Australia for the Paralympic Games movement. It oversees the preparation and management of Australian teams that participate at the Summer Paralympics and the Winter Paralympics.