The Autostrada A18 is a 77 km (48 mi) motorway on the Ionian coast of Sicily that links Messina to Catania. The motorway is linked to the A20 Messina-Palermo at its northern-end and to the A19 Palermo-Catania through the RA15 Catania's Ring Road at its southern-end. There is also a second stretch of A18, of 50 km, on the south part of the island, running from Syracuse to Rosolini, recently extended to Ispica/Pozzallo and Modica.

The Autostrada A20 is a toll motorway on the island of Sicily that links the city of Palermo to Messina. The motorway from Messina follows the Tyrrhenian coast for 181 km (112 mi) until it meets the A19 Palermo-Catania at Buonfornello. The motorway A20, at its eastern-end, is also connected to the A18 Messina-Catania. It's a four lane motorway in its whole length. Consorzio per le Autostrade Siciliane is in charge of toll collection, management, and maintenance of the motorway.