Avenida Presidente Masaryk is a thoroughfare in the affluent Polanco neighborhood of Mexico City. It stretches from Calzada General Mariano Escobedo in the east to Avenida Ferrocarril de Cuernavaca in the west, passing along the north side of the Polanquito restaurant district that borders Parque Lincoln. Masaryk is one of the most expensive shopping districts in the world and competes with Avenida Madero in the Historic Center for the title of street with the highest rents in the city.

Polanco is a neighborhood in the Miguel Hidalgo borough of Mexico City. Polanco is an affluent colonia, noted for its luxury shopping along Presidente Masaryk Avenue, the most expensive street in Mexico, as well as for the numerous prominent cultural institutions located within the neighborhood.